p-Aminohippurate Transport in Rat Renal Brush-Border Membranes. A Potential-Sensitive Transport System and an Anion Exchanger.
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Characterization of Ca2+ transport in rat renal brush-border membranes and its modulation by phosphatidic acid.
The Ca2+ transport process by isolated renal brush-border membranes was characterized and the influence of the acidic phospholipid phosphatidic acid (PtdA) on this transport process was assessed. Ca2+ uptake by brush-border membranes exhibited saturation kinetics. It was inhibitable by a variety of multivalent cations, as well as by Ca2+-entry inhibitors, including verapamil, Ruthenium Red and ...
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This study demonstrates the presence of oxalate transporters on the brush border membrane of rabbit ileum. We found that an inside alkaline (pH = 8.5 inside, 6.5 outside) pH gradient stimulated [14C]oxalate uptake 10-fold at 1 min with a fourfold accumulation above equilibrated uptake at 5 min. 1 mM 4,4'-diisothiocyanostilbene-2,2'-disulfonate (disodium salt; DIDS) profoundly inhibited the pH-g...
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Uptake of L-alanine against a concentration gradient has been shown to occur with isolated brush border membranes from rat small intestine. An alanine transport system, displaying the following characteristics, was shown: (a) L-alanine was taken up and released faster than D-alanine; (b) Na+ as well as Li+ stimulated the uptake of both stereoisomers; (c) the uptake of L- and D-alanine showed sa...
متن کاملCharacteristics of p-aminohippurate transport in proximal renal tubules.
TUNE,BRUCE M., MAURICE B. BURG,AND CLIFFORD SPATLAK. Charac~eri.ctics uf p-aminohippurata transport in proximal renal tubules. Am. J. Physiol. 217(4): 1057-1063. I969,-PAH transport was studied using isolated, perfused rabbit proximal renal tubules. ,4ctive PAH secretion was found in both the convoluted and the straight portion of the proximal tubule, but the rate of secretion was approximately...
متن کاملEssential disulfide and sulfhydryl groups for organic cation transport in renal brush-border membranes.
The disulfide reducing agent, dithiothreitol (DTT) and the sulfhydryl-modifying reagents p-chloromercuribenzenesulfonic acid and N-ethylmaleimide (NEM) were employed to assess the role of disulfide and sulfhydryl groups in organic cation transport. The transport of N1-[3H]methylnicotinamide (NMN), a prototypic organic cation, was examined employing brush-border membrane vesicles isolated from t...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 1993
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.16.395